Motif ID: HOX{A4,D4}.p2

Z-value: 1.182


Transcription factors associated with HOX{A4,D4}.p2:

Gene SymbolEntrez IDGene Name
HOXA4 3201 homeobox A4
HOXD4 3233 homeobox D4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA4chr7_-_27170351-0.481.1e-13Click!


Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_-_34243118 42.454 RBM12
RNA binding motif protein 12
chr10_+_28878666 31.705 WAC
WW domain containing adaptor with coiled-coil
chr10_+_11047253 30.233 NM_001025077
 CELF2
CUGBP, Elav-like family member 2
chr2_+_172821874 29.669 HAT1
histone acetyltransferase 1
chr17_+_18768781 28.741 NM_001243940
 PRPSAP2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr21_+_30400229 26.371 USP16
ubiquitin specific peptidase 16
chr17_+_48821106 21.488 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr10_+_11047274 20.354 CELF2
CUGBP, Elav-like family member 2
chr9_-_86584079 20.035 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr2_+_109204904 19.224 NM_001193488
 LIMS1
LIM and senescent cell antigen-like domains 1
chr1_+_167298280 16.545 NM_001198783
 POU2F1
POU class 2 homeobox 1
chr11_-_67450536 16.292 RPL37
ribosomal protein L37
chr10_-_27057776 15.893 ABI1
abl-interactor 1
chr3_+_63884074 15.296 NM_001177387
 ATXN7
ataxin 7
chr12_-_46633551 15.234 SLC38A1
solute carrier family 38, member 1
chr1_+_84630575 14.996 NM_001242860
NM_001242861
 PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr13_-_41593405 14.946 ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_+_40735749 14.432 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr2_-_225370687 14.166 CUL3
cullin 3
chr9_+_79968344 13.864 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 92 entries
enrichment   p-value GO term description
3.85 3.28e-04 GO:0000216 M/G1 transition of mitotic cell cycle
3.52 3.97e-02 GO:0006367 transcription initiation from RNA polymerase II promoter
3.40 2.47e-04 GO:0000077 DNA damage checkpoint
3.28 5.20e-04 GO:0051320 S phase
3.20 1.47e-03 GO:0000084 S phase of mitotic cell cycle
3.19 8.83e-04 GO:0031570 DNA integrity checkpoint
3.14 8.27e-05 GO:0000082 G1/S transition of mitotic cell cycle
2.73 2.82e-03 GO:0010498 proteasomal protein catabolic process
2.73 2.82e-03 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
2.69 5.36e-05 GO:0071156 regulation of cell cycle arrest
2.65 1.90e-04 GO:0000075 cell cycle checkpoint
2.36 3.84e-02 GO:0046649 lymphocyte activation
2.35 3.89e-03 GO:0045321 leukocyte activation
2.33 5.44e-05 GO:0010564 regulation of cell cycle process
2.15 1.13e-03 GO:0044419 interspecies interaction between organisms
2.13 6.02e-06 GO:0016071 mRNA metabolic process
2.13 1.72e-02 GO:0006366 transcription from RNA polymerase II promoter
2.10 6.89e-04 GO:0016032 viral reproduction
2.05 4.35e-02 GO:0051325 interphase
2.04 2.27e-02 GO:0051603 proteolysis involved in cellular protein catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
6.01 9.46e-03 GO:0005839 proteasome core complex
3.82 1.05e-03 GO:0000502 proteasome complex
3.27 1.60e-02 GO:0005643 nuclear pore
3.08 1.14e-02 GO:0046930 pore complex
2.15 2.61e-02 GO:0000228 nuclear chromosome
1.86 3.79e-04 GO:0005694 chromosome
1.81 2.32e-10 GO:0005654 nucleoplasm
1.81 8.19e-03 GO:0044427 chromosomal part
1.75 1.13e-02 GO:0030529 ribonucleoprotein complex
1.67 2.96e-10 GO:0031981 nuclear lumen
1.66 2.21e-12 GO:0044428 nuclear part
1.64 7.68e-03 GO:0044451 nucleoplasm part
1.62 1.18e-04 GO:0005783 endoplasmic reticulum
1.55 3.04e-09 GO:0031974 membrane-enclosed lumen
1.55 3.36e-09 GO:0043233 organelle lumen
1.55 4.76e-09 GO:0070013 intracellular organelle lumen
1.45 3.23e-05 GO:0005829 cytosol
1.41 8.11e-09 GO:0032991 macromolecular complex
1.37 2.32e-05 GO:0043234 protein complex
1.31 8.35e-10 GO:0005634 nucleus

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
5.01 2.42e-02 GO:0046966 thyroid hormone receptor binding
2.02 1.28e-03 GO:0003712 transcription cofactor activity
2.02 1.39e-03 GO:0000988 protein binding transcription factor activity
2.02 1.39e-03 GO:0000989 transcription factor binding transcription factor activity
1.93 9.08e-08 GO:0003723 RNA binding
1.36 7.67e-21 GO:0005515 protein binding
1.17 1.05e-14 GO:0005488 binding